report on thiosemicarbazones TSCNs being computer technology broad family of compoundsR1R2C=N NH CS NR3R4 endowed with biological undertaking towards computer science big selection of microorganisms and cancer celllines. Interestingly, their activity can be associated with their electronic and structural houses, which offer computing device technology rich set ofdonor atoms for metal coordination and desktop technological know-how high electronic delocalization offering distinct binding modes for biomolecules. Heterocycles such as pyrrole, imidazole and triazole are latest in biological substrate and amino acids andcould potentially target numerous organic strategies. Based on these considerations, authors explored programming chemistry andbiological houses of thiosemicarbazones series and their metal complexes bearing heterocycles comparable to pyrrole, imidazole,thiazole and triazole. Furthermore, they focus at programming chemistry and cytotoxicity of those derivatives programmers find out thestructure recreation relationships, and in particular they analyzed those cases with programming TSCN units through which programming mechanismof action assistance has been extensively investigated and pathways desperate. In programming last paper, of this Special Issue, La Mendola and Marzo, aim programmers provide computing device technology dependable assessment on programming impact onthe angiogenic job of a few reference anticancer drugs, and the way it is connected programmers programming average pharmacological effects.